The Role of HP1 Dimerisation in Maintaining Chromatin Structure

Hippo signaling regulates the nuclear behavior and DNA binding times of YAP and TEAD to control transcription

B Kroeger, SA Manning, V Mohan, J Lou, G Sun, S Lamont, AJ McCann, M Francois, JM Polo, E Hinde, KF Harvey

2025-07-25

Over the past two decades, genetic and proteomic screens have identified the Hippo pathway as a complex signaling network that con..

Pair correlation microscopy of intracellular molecular transport

J Sanchez-Velasquez, A Solano, MA Digman, E Gratton, F Cardarelli, E Hinde

2025-06-01

Pair correlation microscopy is a unique approach to fluorescence correlation spectroscopy that can track the long-range diffusive ..

Histone FRET reports the spatial heterogeneity in nanoscale chromatin architecture that is imparted by the epigenetic landscape at the level of single foci in an intact cell nucleus

Z Liang, A Solano, J Lou, E Hinde

2024-01-01

Genome sequencing has identified hundreds of histone post-translational modifications (PTMs) that define an open or compact chroma..

Radial pair correlation of molecular brightness fluctuations maps protein diffusion as a function of oligomeric state within live-cell nuclear architecture

A Solano, J Lou, L Scipioni, E Gratton, E Hinde

2022-06-07

Nuclear proteins can modulate their DNA binding activity and the exploration volume available during DNA target search by self-ass..

Heterochromatic repeat clustering imposes a physical barrier on homologous recombination to prevent chromosomal translocations

I Mitrentsi, J Lou, A Kerjouan, J Verigos, B Reina-San-Martin, E Hinde, E Soutoglou

2022-06-02

Mouse pericentromeric DNA is composed of tandem major satellite repeats, which are heterochromatinized and cluster together to for..